IRIFIV Research

Luteal progesterone level correlated with immunotherapy success of patients with repeated implantation failures

A Fertility Research Publication from IRIFIV – Centre de Fertilité Casablanca, Maroc

Authors

Noureddine Louanjli, Omar Sefrioui, Aicha Madkour, Ismail Kaarouch, Brahim Saadani, Said Assou, Nouzha Bouamoud, Saaid Amzazi, Henri Copin, Moncef Benkhalifa, Noureddine Louanjli

Journal / Date

Journal of Medical and Research Publications - Gynecology and Urology

Introduction & Clinical Relevance:

This significant scientific study from the IRIFIV Fertility Center in Casablanca, Morocco, addresses a critical challenge in Assisted Reproductive Technology (ART): Repeated Implantation Failure (RIF). For patients experiencing the heartbreak of multiple unsuccessful embryo transfers, this research led by Dr. Noureddine Louanjli offers a vital clinical insight. It investigates the correlation between Luteal Progesterone Levels (LPL) and the success of a specific immunotherapy treatment using the patient's own immune cells (Peripheral Blood Mononuclear Cells - PBMCs).
The clinical relevance of this publication is paramount for advancing personalized fertility care. The findings suggest that measuring a patient's progesterone level after transfer could serve as a predictive biomarker for the success of immunotherapy in RIF cases. This allows for more tailored and precise treatment strategies, moving beyond a "one-size-fits-all" approach. By demonstrating how maternal immune response interacts with hormonal support, this research reinforces IRIFIV's leadership in complex infertility management and its commitment to implementing evidence-based, innovative treatments to improve clinical pregnancy rates for patients in Morocco and internationally.

Abstract:

Problem: Immunotherapy using PBMC administration demonstrated relatively its effectiveness to treat RIF patients but it is still unclear to explain some miscarriages. However, we could hypothesize a presence of dual interactive action between Luteal progesterone level (LPL) synthesized by corpus luteum after embryo implantation stage and the stimulated immune maternal system by immunotherapy. This issue could be informative basis data to personalize immunotherapy for RIF patients based on LPL predicting clinical outcomes. Method of Study: This randomized controlled study included 70 patients undergoing ICSI program presenting at least 3 RIF: 39 for Control of untreated patients and 31 for PBMC-test concerning treated patients with immunotherapy. For the PBMC-test group, Peripheral Blood Mononuclear Cells (PBMCs) were isolated from patients on ovulation induction day and cultured three days to be administered to the intrauterine cavity of patients two days before fresh embryo transfer. LPL was analyzed at day 15 after embryo transfer and clinical outcomes were calculated including implantation, clinical pregnancy and miscarriage rates. Results: Clinical outcomes were doubly improved after immunotherapy including implantation and clinical pregnancy rates comparing Control versus PBMC-test (10% and 21% vs 24% and 45%). On the other hand, this strategy showed an increase over double in LPL (4ng/ml for Control vs 9ng/ml for PBMC-test) while the latter was correlated to clinical pregnancy. Conclusions: Bypassing the effectiveness of this immunotherapy approach for RIF patients, is directly correlated to LPL proving the interactive reaction between the immune profile of the treated patients and progesterone synthesis by corpus luteum.

Keywords:

Luteal progesterone level, repeated implantation failure RIF, immunotherapy for infertility, PBMC treatment, implantation success, progesterone correlation, personalized fertility treatment, IRIFIV Casablanca, Dr. Noureddine Louanjli, recurrent IVF failure, reproductive immunology

IRIFIV Research

Luteal progesterone level correlated with immunotherapy success of patients with repeated implantation failures

A Fertility Research Publication from IRIFIV – Centre de Fertilité Casablanca, Maroc

Authors

Noureddine Louanjli, Omar Sefrioui, Aicha Madkour, Ismail Kaarouch, Brahim Saadani, Said Assou, Nouzha Bouamoud, Saaid Amzazi, Henri Copin, Moncef Benkhalifa, Noureddine Louanjli

Journal / Date

Journal of Medical and Research Publications - Gynecology and Urology

Introduction & Clinical Relevance:

This significant scientific study from the IRIFIV Fertility Center in Casablanca, Morocco, addresses a critical challenge in Assisted Reproductive Technology (ART): Repeated Implantation Failure (RIF). For patients experiencing the heartbreak of multiple unsuccessful embryo transfers, this research led by Dr. Noureddine Louanjli offers a vital clinical insight. It investigates the correlation between Luteal Progesterone Levels (LPL) and the success of a specific immunotherapy treatment using the patient's own immune cells (Peripheral Blood Mononuclear Cells - PBMCs).
The clinical relevance of this publication is paramount for advancing personalized fertility care. The findings suggest that measuring a patient's progesterone level after transfer could serve as a predictive biomarker for the success of immunotherapy in RIF cases. This allows for more tailored and precise treatment strategies, moving beyond a "one-size-fits-all" approach. By demonstrating how maternal immune response interacts with hormonal support, this research reinforces IRIFIV's leadership in complex infertility management and its commitment to implementing evidence-based, innovative treatments to improve clinical pregnancy rates for patients in Morocco and internationally.

Abstract:

Problem: Immunotherapy using PBMC administration demonstrated relatively its effectiveness to treat RIF patients but it is still unclear to explain some miscarriages. However, we could hypothesize a presence of dual interactive action between Luteal progesterone level (LPL) synthesized by corpus luteum after embryo implantation stage and the stimulated immune maternal system by immunotherapy. This issue could be informative basis data to personalize immunotherapy for RIF patients based on LPL predicting clinical outcomes. Method of Study: This randomized controlled study included 70 patients undergoing ICSI program presenting at least 3 RIF: 39 for Control of untreated patients and 31 for PBMC-test concerning treated patients with immunotherapy. For the PBMC-test group, Peripheral Blood Mononuclear Cells (PBMCs) were isolated from patients on ovulation induction day and cultured three days to be administered to the intrauterine cavity of patients two days before fresh embryo transfer. LPL was analyzed at day 15 after embryo transfer and clinical outcomes were calculated including implantation, clinical pregnancy and miscarriage rates. Results: Clinical outcomes were doubly improved after immunotherapy including implantation and clinical pregnancy rates comparing Control versus PBMC-test (10% and 21% vs 24% and 45%). On the other hand, this strategy showed an increase over double in LPL (4ng/ml for Control vs 9ng/ml for PBMC-test) while the latter was correlated to clinical pregnancy. Conclusions: Bypassing the effectiveness of this immunotherapy approach for RIF patients, is directly correlated to LPL proving the interactive reaction between the immune profile of the treated patients and progesterone synthesis by corpus luteum.

Keywords:

Luteal progesterone level, repeated implantation failure RIF, immunotherapy for infertility, PBMC treatment, implantation success, progesterone correlation, personalized fertility treatment, IRIFIV Casablanca, Dr. Noureddine Louanjli, recurrent IVF failure, reproductive immunology

Le Département de Recherche Scientifique d’IRIFIV Centre de Fertilité à Casablanca (Maroc) est dédié à l’avancement de la médecine de la reproduction, de la FIV et des approches diagnostiques innovantes. Les travaux de recherche menés par l’équipe IRIFIV contribuent au développement de nouvelles stratégies cliniques, biologiques et génétiques visant à améliorer la prise en charge de l’infertilité et des pathologies gynécologiques complexes.

À propos du département de recherche scientifique de l’IRIFIV

Le Département de Recherche Scientifique d’IRIFIV Centre de Fertilité à Casablanca (Maroc) est dédié à l’avancement de la médecine de la reproduction, de la FIV et des approches diagnostiques innovantes. Les travaux de recherche menés par l’équipe IRIFIV contribuent au développement de nouvelles stratégies cliniques, biologiques et génétiques visant à améliorer la prise en charge de l’infertilité et des pathologies gynécologiques complexes.

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Fondé en 1992, avec plus de 34 ans d’expérience et des milliers de bébés nés, IRIFIV Casablanca est le premier centre structuré marocain de procréation médicalement assistée et l’un des centres de fertilité et FIV les plus reconnus à Casablanca et au Maroc. La clinique est spécialisée dans tous les cas d’infertilité, y compris les cas complexes. Nous utilisons des technologies et équipements de dernière génération, dont certains uniques au Maroc. IRIFIV et le laboratoire Labomac constituent un terrain de stage pratique en FIV dans le cadre du Diplôme Universitaire de Biologie et Génétique de la Reproduction de l’Université Mohammed VI des Sciences de la Santé, et sont actifs en recherche, formation médicale et collaborations internationales.

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IRIFIV Research

Luteal progesterone level correlated with immunotherapy success of patients with repeated implantation failures

A Fertility Research Publication from IRIFIV – Centre de Fertilité Casablanca, Maroc

Authors

Noureddine Louanjli, Omar Sefrioui, Aicha Madkour, Ismail Kaarouch, Brahim Saadani, Said Assou, Nouzha Bouamoud, Saaid Amzazi, Henri Copin, Moncef Benkhalifa, Noureddine Louanjli

Journal / Date

Journal of Medical and Research Publications - Gynecology and Urology

12/01/2021

Introduction & Clinical Relevance:

Abstract:

Keywords:

Luteal progesterone level, repeated implantation failure RIF, immunotherapy for infertility, PBMC treatment, implantation success, progesterone correlation, personalized fertility treatment, IRIFIV Casablanca, Dr. Noureddine Louanjli, recurrent IVF failure, reproductive immunology

IRIFIV Research

Luteal progesterone level correlated with immunotherapy success of patients with repeated implantation failures

A Fertility Research Publication from IRIFIV – Centre de Fertilité Casablanca, Maroc

Authors

Noureddine Louanjli, Omar Sefrioui, Aicha Madkour, Ismail Kaarouch, Brahim Saadani, Said Assou, Nouzha Bouamoud, Saaid Amzazi, Henri Copin, Moncef Benkhalifa, Noureddine Louanjli

Journal / Date

Journal of Medical and Research Publications - Gynecology and Urology

12/01/2021

Introduction & Clinical Relevance:

Abstract:

Keywords:

Luteal progesterone level, repeated implantation failure RIF, immunotherapy for infertility, PBMC treatment, implantation success, progesterone correlation, personalized fertility treatment, IRIFIV Casablanca, Dr. Noureddine Louanjli, recurrent IVF failure, reproductive immunology

À propos du département de recherche scientifique de l’IRIFIV

À propos du département de recherche scientifique de l’IRIFIV

Vous aimerez aussi

IRIFIV Research

Acomprehensive review about sperm-oocyte interactions and key activation factors of fertilization in mammals

IRIFIV Research

Epidemiological, Clinical, and Biomarker Profile of Male Infertility in Morocco: A Retrospective Single-Center Study of 1399 Cases

IRIFIV Research

Mutations in the protamine locus: Association with spermatogenic failure?

prêt à démarrer votre projet parental?

prêt à démarrer votre projet parental ?

Nos Services

À PROPOS

RESOURCES

PATIENTS INTERNATIONAUX

ARTICLES RÉCENTS

Le 1er Centre multidisciplinaire structuré d’Assistance Médicale à la Procréation (AMP) au Maroc

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+212 5 22 94 97 72

+212 5 22 94 97 72