IRIFIV Research

Session 70: Genetics: what genomes gone wrong can tell us

A Fertility Research Publication from IRIFIV – Centre de Fertilité Casablanca, Maroc

Authors

Noureddine Louanjli, E. Elinati, P. Kuentz, C. Redin, F. V. Meerschaut, M. Nasr-Esfahani, T. Gurgan, N. Louanjli, N. Iqbal, F. Pigeon, H. Gourabi, F. Brugnon, S. Gitlin, P. Sutter, J. Muller, S. Viville, E. Dul, J. Echten-Arends, H. Groen, P. Kastrop, L. Wissen, J. Engelen, J. Land, E. Coonen, C. Werken, G. V. D. Heijden, C.J.H. van Veen-Buurman, J. Laven, A.H.F.M. Peters, E. Baart, M. Rabinowitz, G. Gemelos, M. Banjevic, B. Zimmermann, J. Banér, B. Levy, M. Hill, A. Mertzanidou, C. Spits, H. Velde, K. Sermon, D. Wells, S. Alfarawati, M. Konstantinidis, S. Jaroudi, E. Fragouli, M. Minasi, A. Ruberti, P. Rubino, E. Iammarrone, A. Biricick, D. Zavaglia, A. Nuccitelli, A. Colasante, F. Fiorentino, E. Greco

Journal / Date

Introduction & Clinical Relevance:

This conference session abstract from the prestigious journal Human Reproduction features contributions from a global consortium of leading fertility experts, including Dr. Noureddine Louanjli of IRIFIV Fertility Center. The session, titled "Genetics: What Genomes Gone Wrong Can Tell Us," delves into the fundamental genetic underpinnings of human infertility, using abnormal conditions as a lens to understand normal gametogenesis (sperm and egg development).
The clinical relevance of this collective research is foundational to advancing reproductive medicine. It addresses the observed global decline in semen quality and the rise of conditions like testicular dysgenesis syndrome (TDS). The session proposes that studying genetic causes of infertility, such as globozoospermia (a condition where sperm lack a critical structure for egg fertilization), provides crucial insights into normal reproductive biology. For patients at IRIFIV and worldwide, this type of research is the bedrock of progress. By unraveling the genetic basis of conditions like globozoospermia, scientists and clinicians can develop more accurate diagnostic tests, understand the heritability of certain infertility factors, and pave the way for targeted treatments. This work underscores IRIFIV's active role in international collaborative research aimed at translating genetic discoveries into improved clinical outcomes for couples struggling to conceive.

Abstract:

During the last 5 or 6 decades a large number of reports have been devoted to the decline in semen quality among men. This drop in sperm concentration parallels an increase of the incidence of testicular cancer, of cryptorchidism and of hypospadias. All these symptoms have been proposed to be part of a unique entity, the testicular dysgenesis syndrome (TDS). So far a controversy is still ongoing about the reasons of this decrease in sperm counts and other semen quality variables. We believe that this controversy can mainly be attributed to our poor understanding of human gametogenesis and this because of the absence of a proper human model. We are convinced that one way to decipherer human gametogenesis is to study the genetics of infertility. We present here, as an example, the link between the genetic aspects and the clinical outcomes of globozoospermia, by describing the largest cohort of globozoospermic patients to date.

Keywords:

Genetics of infertility, gametogenesis, globozoospermia, testicular dysgenesis syndrome TDS, sperm quality decline, genetic research reproduction, aneuploidy, Human Reproduction journal, IRIFIV Casablanca, Dr. Noureddine Louanjli

IRIFIV Research

Session 70: Genetics: what genomes gone wrong can tell us

A Fertility Research Publication from IRIFIV – Centre de Fertilité Casablanca, Maroc

Authors

Noureddine Louanjli, E. Elinati, P. Kuentz, C. Redin, F. V. Meerschaut, M. Nasr-Esfahani, T. Gurgan, N. Louanjli, N. Iqbal, F. Pigeon, H. Gourabi, F. Brugnon, S. Gitlin, P. Sutter, J. Muller, S. Viville, E. Dul, J. Echten-Arends, H. Groen, P. Kastrop, L. Wissen, J. Engelen, J. Land, E. Coonen, C. Werken, G. V. D. Heijden, C.J.H. van Veen-Buurman, J. Laven, A.H.F.M. Peters, E. Baart, M. Rabinowitz, G. Gemelos, M. Banjevic, B. Zimmermann, J. Banér, B. Levy, M. Hill, A. Mertzanidou, C. Spits, H. Velde, K. Sermon, D. Wells, S. Alfarawati, M. Konstantinidis, S. Jaroudi, E. Fragouli, M. Minasi, A. Ruberti, P. Rubino, E. Iammarrone, A. Biricick, D. Zavaglia, A. Nuccitelli, A. Colasante, F. Fiorentino, E. Greco

Journal / Date

Introduction & Clinical Relevance:

This conference session abstract from the prestigious journal Human Reproduction features contributions from a global consortium of leading fertility experts, including Dr. Noureddine Louanjli of IRIFIV Fertility Center. The session, titled "Genetics: What Genomes Gone Wrong Can Tell Us," delves into the fundamental genetic underpinnings of human infertility, using abnormal conditions as a lens to understand normal gametogenesis (sperm and egg development).
The clinical relevance of this collective research is foundational to advancing reproductive medicine. It addresses the observed global decline in semen quality and the rise of conditions like testicular dysgenesis syndrome (TDS). The session proposes that studying genetic causes of infertility, such as globozoospermia (a condition where sperm lack a critical structure for egg fertilization), provides crucial insights into normal reproductive biology. For patients at IRIFIV and worldwide, this type of research is the bedrock of progress. By unraveling the genetic basis of conditions like globozoospermia, scientists and clinicians can develop more accurate diagnostic tests, understand the heritability of certain infertility factors, and pave the way for targeted treatments. This work underscores IRIFIV's active role in international collaborative research aimed at translating genetic discoveries into improved clinical outcomes for couples struggling to conceive.

Abstract:

During the last 5 or 6 decades a large number of reports have been devoted to the decline in semen quality among men. This drop in sperm concentration parallels an increase of the incidence of testicular cancer, of cryptorchidism and of hypospadias. All these symptoms have been proposed to be part of a unique entity, the testicular dysgenesis syndrome (TDS). So far a controversy is still ongoing about the reasons of this decrease in sperm counts and other semen quality variables. We believe that this controversy can mainly be attributed to our poor understanding of human gametogenesis and this because of the absence of a proper human model. We are convinced that one way to decipherer human gametogenesis is to study the genetics of infertility. We present here, as an example, the link between the genetic aspects and the clinical outcomes of globozoospermia, by describing the largest cohort of globozoospermic patients to date.

Keywords:

Genetics of infertility, gametogenesis, globozoospermia, testicular dysgenesis syndrome TDS, sperm quality decline, genetic research reproduction, aneuploidy, Human Reproduction journal, IRIFIV Casablanca, Dr. Noureddine Louanjli

Le Département de Recherche Scientifique d’IRIFIV Centre de Fertilité à Casablanca (Maroc) est dédié à l’avancement de la médecine de la reproduction, de la FIV et des approches diagnostiques innovantes. Les travaux de recherche menés par l’équipe IRIFIV contribuent au développement de nouvelles stratégies cliniques, biologiques et génétiques visant à améliorer la prise en charge de l’infertilité et des pathologies gynécologiques complexes.

À propos du département de recherche scientifique de l’IRIFIV

Le Département de Recherche Scientifique d’IRIFIV Centre de Fertilité à Casablanca (Maroc) est dédié à l’avancement de la médecine de la reproduction, de la FIV et des approches diagnostiques innovantes. Les travaux de recherche menés par l’équipe IRIFIV contribuent au développement de nouvelles stratégies cliniques, biologiques et génétiques visant à améliorer la prise en charge de l’infertilité et des pathologies gynécologiques complexes.

Vous aimerez aussi

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Acomprehensive review about sperm-oocyte interactions and key activation factors of fertilization in mammals
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Epidemiological, Clinical, and Biomarker Profile of Male Infertility in Morocco: A Retrospective Single-Center Study of 1399 Cases
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Mutations in the protamine locus: Association with spermatogenic failure?
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IRIFIV is a multidisciplinary fertility center in Casablanca, Morocco, specializing in IVF and ICSI. Since 1992, over 32 years of expertise and thousands of successful births demonstrate our commitment. We offer all techniques to evaluate and treat infertility with a personalized approach, multidisciplinary team, latest technology, complementary therapies, scientific research, teaching, professional development, and international collaboration.

Le 1er Centre multidisciplinaire structuré d’Assistance Médicale à la Procréation (AMP) au Maroc

Fondé en 1992, avec plus de 34 ans d’expérience et des milliers de bébés nés, IRIFIV Casablanca est le premier centre structuré marocain de procréation médicalement assistée et l’un des centres de fertilité et FIV les plus reconnus à Casablanca et au Maroc. La clinique est spécialisée dans tous les cas d’infertilité, y compris les cas complexes. Nous utilisons des technologies et équipements de dernière génération, dont certains uniques au Maroc. IRIFIV et le laboratoire Labomac constituent un terrain de stage pratique en FIV dans le cadre du Diplôme Universitaire de Biologie et Génétique de la Reproduction de l’Université Mohammed VI des Sciences de la Santé, et sont actifs en recherche, formation médicale et collaborations internationales.

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IRIFIV Research

Session 70: Genetics: what genomes gone wrong can tell us

A Fertility Research Publication from IRIFIV – Centre de Fertilité Casablanca, Maroc

Authors

Journal / Date

Human Reproduction

01/01/2012

Introduction & Clinical Relevance:

Abstract:

Keywords:

Genetics of infertility, gametogenesis, globozoospermia, testicular dysgenesis syndrome TDS, sperm quality decline, genetic research reproduction, aneuploidy, Human Reproduction journal, IRIFIV Casablanca, Dr. Noureddine Louanjli

IRIFIV Research

Session 70: Genetics: what genomes gone wrong can tell us

A Fertility Research Publication from IRIFIV – Centre de Fertilité Casablanca, Maroc

Authors

Journal / Date

Human Reproduction

01/01/2012

Introduction & Clinical Relevance:

Abstract:

Keywords:

Genetics of infertility, gametogenesis, globozoospermia, testicular dysgenesis syndrome TDS, sperm quality decline, genetic research reproduction, aneuploidy, Human Reproduction journal, IRIFIV Casablanca, Dr. Noureddine Louanjli

À propos du département de recherche scientifique de l’IRIFIV

À propos du département de recherche scientifique de l’IRIFIV

Vous aimerez aussi

IRIFIV Research

Acomprehensive review about sperm-oocyte interactions and key activation factors of fertilization in mammals

IRIFIV Research

Epidemiological, Clinical, and Biomarker Profile of Male Infertility in Morocco: A Retrospective Single-Center Study of 1399 Cases

IRIFIV Research

Mutations in the protamine locus: Association with spermatogenic failure?

prêt à démarrer votre projet parental?

prêt à démarrer votre projet parental ?

Nos Services

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RESOURCES

PATIENTS INTERNATIONAUX

ARTICLES RÉCENTS

Le 1er Centre multidisciplinaire structuré d’Assistance Médicale à la Procréation (AMP) au Maroc

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+212 5 22 94 97 72

+212 5 22 94 97 72