IRIFIV Research publication

Association of spermatogenic failure with the b2/b3 partial AZFc deletion

Authors

Noureddine Louanjli, Abdelmajid Eloualid, Houria Rhaissi, Ahmed Réguig, Safaa Bounaceur, Brahim El Houate, Omar Abidi, Majida Charif, Noureddine Louanjli, Elbakkay Chadli, Abdelhamid Barakat, Anu Bashambou, Ken Mc Elreavey, Hassan Rouba

Revue Scientifique

PLoS ONE

/ April 13, 2012

Abstract: Infertility affects around 1 in 10 men and in most cases the cause is unknown. The Y chromosome plays an important role in spermatogenesis and specific deletions of this chromosome, the AZF deletions, are associated with spermatogenic failure. Recently partial AZF deletions have been described but their association with spermatogenic failure is unclear. Here we screened a total of 339 men with idiopathic spermatogenic failure, and 256 normozoospermic ancestry-matched men for chromosome microdeletions including AZFa, AZFb, AZFc, and the AZFc partial deletions (gr/gr, b1/b3 and b2/b3). AZFa and AZFc deletions were identified in men with severe spermatogenic failure at similar frequencies to those reported elsewhere. Gr/gr deletions were identified in case and control populations at 5.83% and 6.25% respectively suggesting that these deletions are not associated with spermatogenic failure. However, b2/b3 deletions were detected only in men with spermatogenic failure and not in the normospermic individuals. Combined with our previous data this shows an association of the b2/b3 deletion (p = 0.0318) with spermatogenic failure in some populations. We recommend screening for this deletion in men with unexplained spermatogenic failure.

Keywords:

IRIFIV Research publication

Association of spermatogenic failure with the b2/b3 partial AZFc deletion

By root/Published On: April 13, 2012/Categories: Research publication/0 Comments/

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IRIFIV Research publication

Association of spermatogenic failure with the b2/b3 partial AZFc deletion

Authors

Revue Scientifique

IRIFIV Research publication

Association of spermatogenic failure with the b2/b3 partial AZFc deletion

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